PROLINE AND HYDROXYPROLINE IN NUTRITION
نویسندگان
چکیده
منابع مشابه
Rapid robust separation of hydroxyproline and proline.
The presence of hydroxyproline, and the determination of the ratio of the secondary amino acids proline to hydroxyproline, in amino acid hydrolysates specifically identifies collagen and collagen peptides. o-Phthalaldehyde, and then 9-fluorenylmethyl chloroformate, were used to carry out sequential prederivatization of amino acid hydrolysates in an in-line high-performance liquid chromatography...
متن کاملThe role of hydroxyproline in collagen folding: conformational energy calculations on oligopeptides containing proline and hydroxyproline.
We have observed that the rate of folding of the enzymatically hydroxylated form of poly(G1yPro-Pro) into the triple-helical conformation is considerably higher than that of the unhydroxylated polypeptide [R. K. Chopra and V. S. Ananthanarayanan (1982) Proc. Nutl. Acud. Sci. USA 79, 7180-71841. In this study, we examine a plausible kinetic pathway for triple-helix formation by selecting peptide...
متن کاملPrevalence of proline racemase/ hydroxyproline epimerase gene in human brucella isolates in Iran
Background: Human brucellosis is a zoonotic disease caused by Brucella melitensis, Brucella abortus, and Brucella suis. Brucella causes a chronic disease, which subverts the immune defense system of their hosts. In this study, the prevalence of an important Brucella virulence determinant, PrpA, which can modulate immune response, was determined in human isolates. Methods: Polymerase chain reac...
متن کاملConversion of proline to hydroxyproline and its incorporation into collagen.
Most, if not all, of the hydroxyproline in collagen appears to be derived from proline (1, 2). It has been proposed by several investigators (2-7), on indirect evidence, that it is a bound form of proline which is hydroxylated and incorporated into collagen. Recent data (8-11) indicate an analogous situation in the hydroxylation of lysine and its incorporation into collagen. The type of compoun...
متن کاملSynthesis of proline and hydroxyproline peptides; their cleavage by prolinase.
Two types of peptidases are known to hydrolyze peptides containing proline and hydroxyproline. The first of these, prolidase (l-3), attacks peptide bonds involving t,he nitrogen of the imino acids in the typical substrates, glycyl-L-proline and glycylhydroxy+proline. The individuality of this enzyme has already been demonstrated by purification and by specificity studies. The second enzyme, nam...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1932
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)76104-8